Terraza is engineered to be among the safest vehicles in the mid-van segment, providing outstanding performance in real-world crashes. Notable features include structural enhancements to its frame using high-strength steel. Terraza's front-end compartment incorporates a large crush zone to preserve interior space, while the engine compartment side frame rails are designed to absorb energy in the event of a frontal impact.

In recently released impact ratings by the National Highway Traffic Safety Administration (NHTSA), GM's new generation of crossover sport vans received a maximum five-star rating for both the driver and front passenger in a frontal impact, as well as for the side impact into the rear seat. The vehicles received a four-star rating for side impact tests of the front seat without the optional side-impact air bags.

In addition to the available side-impact air bags, Terraza has standard dual-stage driver and front-passenger frontal air bags to provide supplemental protection for front seat passengers. Terraza also is equipped with LATCH (Lower Anchors and top Tethers for CHildren) system anchors for child safety seats in all second-row seats

As with all Buick models for 2006, Terraza comes standard with GM's OnStar Safe & Sound package using OnStar's dual-mode (analog-digital) equipment. OnStar's digital equipment also includes enhanced hands-free voice recognition capabilities including more intuitive continuous digit dialing and improved voice recognition accuracy. OnStar is the leading provider of in-vehicle safety, security and information services in the United States and Canada . Using the GPS satellite network and wireless technology, OnStar features core safety services and OnStar Hands-Free Calling that allows drivers to make and receive voice-activated phone calls using an externally mounted antenna for greater reception.

The OnStar service standard on the 2006 Terraza includes the General Motors Advanced Automatic Crash Notification (AACN) system, making crash data available to participating 911 centers to help them dispatch the appropriate life-saving personnel and equipment to crash scenes faster.