Described by Buick as having a "refined ruggedness," the Rendezvous has an overall shape like that of an SUV, augmented by details that promote a youthful image. Sharp lines take precedence over curves, and Buick gave it a rear slope in contrast to the typically boxy SUV shape. It shares styling elements with other Buicks, including a painted, oval-shaped grille.

Eight-spoke 16-inch wheels are standard on CX models, but others get 17-inch tires. Each Rendezvous rides a 112.2-inch wheelbase, measures 186.5 inches long overall and stands 68.9 inches tall. A fully independent suspension aims to ease the ride quality.