The chassis and structural systems were developed in Germany and give the Buick Regal the handling and dynamics of a premium European sport sedan, as well as the quiet, refined ride and road manners expected of a Buick. The body structure is one of the most rigid in the segment, which is approximately 25-percent stiffer than the previous Buick Regal. This solid structure supports more precise suspension tuning and a quieter ride.

A relatively long wheelbase of 107.8 inches (2738 mm) gives the Buick Regal refined, well-balanced vehicle dynamics and supports comfortable ride tuning. Additionally, an independent MacPherson strut-type front suspension with single-path mountings and hydraulic ride bushings; a four-link independent rear suspension; hydraulic rack-and-pinion steering; and optimized four-wheel disc brakes are optimized to the capability of the individual powertrains and tailored to the expected use by drivers. Models equipped with the 2.0L turbo engine, for example, feature larger brakes.

Latest-generation electronic stability control (ESC or StabiliTrak), anti-lock brake system (ABS), and traction control system (TCS) are standard with Buick's innovative, Interactive Drive Control System (IDCS) real-time damping system offered on models equipped with the 2.0L turbo powertrain.