Buick's long heritage of leading designs, such as the Y-Job Concept, the Roadmaster and the Riviera, helped define American automobile design through the years, according to Ed Welburn, vice president of GM Global Design. Today, Buick design is a product of a global team and resources. Creative collaboration between designers in the United States and China, in partnership with the Pan Asia Technical Automotive Center (PATAC) as well as chassis and body engineers in Europe, resulted in the first General Motors vehicle to be created on three continents.

"The new Buick LaCrosse is intended to represent modern elegance," said Welburn. "Throughout the design, you experience a balance of contrasts. Both the interior and exterior have been designed with harmony in mind. The exterior balances taut, sculpted lines with sensuous accents and surfaces. Inside, smoked chrome accents, warm wood, first-class leather and materials combine with cool blue ambient lighting to create an inviting environment."

The exterior design is faithful to the Buick Invicta Concept introduced at the 2008 Beijing Auto Show.

"It is instantly recognizable as a Buick, with its signature 'sweep spear' body-side styling, portholes inside the character line on the hood, and waterfall grille," added Welburn.